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. 2020 Dec 2;12(12):2890. doi: 10.3390/polym12122890

Figure 5.

Figure 5

(A) Schematic illustration of the synthesis of nitric oxide donor-containing polycarbonate-based micelles (NO-M) for reduction-triggered drug delivery. (B) Intracellular NO release from NO-M in MCF7/DOX resistant cells determined by Griess reagent treatment and observed by fluorescence microscopy (C). (D) Detection of P-gP expression in MCF7/DOX resistant cells incubated with nitric oxide donor-containing aliphatic polycarbonates (APC)-based micelles at different concentrations by Western blot assay. (E) Fluorescence images and flow cytometer analysis for cellular uptake of free DOX in MCF7/DOX resistant cells with and without 24 h pretreatment of nitric oxide donor-containing micelles (1.0 mg/mL). The scale bars represent 50 μm. Reprinted with permission from ref [119]. Copyright 2019 American Chemical Society.