Table 5.
NFE2L2 mutations occur alongside mutations in other genes in NSCLC *.
| NFE2L2 Mutant Samples | |||
|---|---|---|---|
| Gene | Alteration | Co-Occurrence or Mutual Exclusivity with NFE2L2 Mutation | |
| Number of NFE2L2 Mutant Samples with the Alteration | Number of NFE2L2 Wildtype Samples with the Alteration | ||
| KEAP1 | 6(6.7%) | 155(15%) | Mutual exclusivity |
| CUL3 | 5 (4.8%) | 34(3.3%) | Co-occurrence |
| KRAS | 5 (4.8%) | 217 (20.9%) | Mutual exclusivity |
| TP53 | 88 (83.8%) | 687 (66.1%) | Co-occurrence |
| PIK3CA | 12 (11.4%) | 82 (7.9%) | Co-occurrence |
| PTEN | 5 (4.8%) | 62 (6%) | Mutual exclusivity |
| STK11 | 3 (2.9%) | 108 (10.4%) | Mutual exclusivity |