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. 2020 Dec 2;8(12):562. doi: 10.3390/biomedicines8120562

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Analysis of Nb11 expression and toxicity in mice treated with AAV vectors. C57BL/6 mice received one dose of the indicated AAV-Nb11 vectors systemically (10¹¹ vg/mouse), and expression of Nb11 was analyzed over time by measuring its levels in serum with a hPD-1 binding ELISA. (a) Serum levels of Nb11 in mice that received AAV8 particles coding for Nb11 under different promoters (n = 3). Data represent mean + SEM. (b) Serum levels of Nb11 in mice treated with AAV-CAG-C11 or saline (n = 12). (c) Serum levels of TNFα, AST, and ALT in mice treated with AAV-CAG-C11 or saline. Data represent mean ± SEM. ** p < 0.01, *** p < 0.001, **** p < 0.0001; ns: not significant.