Figure 6.

Priming with wP vaccine leads to elevated anti-PT neutralizing antibody titers. PT neutralization was assessed in the Chinese Hamster Ovary (CHO) cell cytotoxicity assay. The data shown at each time point are the mean values from 6 individual animals and the corresponding lines indicate the 95% CI. A statistical analysis was performed using two different models: (i) ANOVA model with the specific primary vaccine immunization (aP or wP) as the fixed factor for days 57, 147, 181, and 196. (ii) ANCOVA model with group as the fixed factor and time as the covariate for the interval between days 196 to 609. The p values are shown in the figure.