Figure 7.

Priming with wP vaccine leads to higher serum bactericidal antibody titers. The serum bactericidal antibody response was measured in a classical killing assay against Bordetella pertussis. The data shown at each time point are the mean values from 6 individual animals and the 95% CI is noted with the corresponding lines. A statistical analysis was performed using two different models: (i) ANOVA model with the specific primary vaccine immunization (aP or wP) as the fixed factor for days 14, 42, 57, 77, 133, 147, 181, and 196. (ii) ANCOVA model with group as the fixed factor and time as the covariate for the interval between days 196 to 609. The p values are listed on the graph.