Table 1.
Cohort characteristics and univariate analysis of tumor recurrence (chi-square test).
| Variable | Complete Cohort | 5-Year Follow-Up Cohort | ||||||
|---|---|---|---|---|---|---|---|---|
| N (%) | Tumor Recurrence n (%) | p-Value | N (%) | Tumor Recurrence n (%) | p-Value | |||
| Yes | No | Yes | No | |||||
| Gender | ||||||||
| Female | 1115 (73.5) | 149 (13.4) | 966 (86.6) | <0.0001 * | 391 (71.1) | 149 (38.1) | 242 (61.9) | <0.0001 * |
| Male | 402 (26.5) | 93 (23.1) | 309 (76.9) | 159 (28.9) | 93 (58.5) | 66 (41.5) | ||
| Tumor localization | ||||||||
| Skull base | 788 (51.9) | 139 (17.6) | 649 (82.4) | <0.0001 * | 296 (53.8) | 139 (47.0) | 157 (53.0) | 0.0032 * |
| Convexity/falx | 574 (37.8) | 98 (17.1) | 476 (82.9) | 222 (40.4) | 98 (44.1) | 124 (55.9) | ||
| Spinal | 155 (10.2) | 5 (3.2) | 150 (96.8) | 32 (5.8) | 5 (15.6) | 27 (84.4) | ||
| Simpson grade | ||||||||
| 1 | 366 (24.8) | 40 (10.9) | 326 (89.1) | <0.0001 * | 120 (22.6) | 40 (33.3) | 80 (66.7) | <0.0001 * |
| 2 | 411 (27.8) | 27 (6.6) | 384 (93.4) | 105 (19.7) | 27 (25.7) | 78 (74.3) | ||
| 3 | 308 (20.8) | 48 (15.6) | 260 (84.4) | 112 (21.1) | 48 (42.9) | 64 (57.1) | ||
| 4 | 393 (26.6) | 122 (31.0) | 271 (69.0) | 195 (36.7) | 122 (62.6) | 73 (37.4) | ||
| 5 | 0 (-) | 0 (-) | 0 (-) | 0 (-) | 0 (-) | 0 (-) | ||
| CNS invasion by histopathological assessment alone | ||||||||
| Yes | 73 (4.8) | 26 (35.6) | 47 (64.4) | <0.0001 * | 36 (6.6) | 26 (72.2) | 10 (27.8) | 0.0004 * |
| No | 1444 (95.2) | 216 (15.0) | 1228 (85.0) | 514 (93.5) | 216 (42.0) | 298 (58.0) | ||
| CNS invasion by intraoperative assessment alone | ||||||||
| Yes | 345 (23.7) | 76 (22.0) | 269 (78.0) | 0.0002 * | 136 (26.4) | 76 (55.9) | 60 (44.1) | 0.0011 * |
| No | 1110 (76.3) | 151 (13.6) | 959 (86.4) | 380 (73.6) | 151 (39.7) | 229 (60.3) | ||
| CNS invasion by combined assessment | ||||||||
| Yes | 372 (25.6) | 85 (22.9) | 287 (77.2) | <0.0001 * | 149 (28.9) | 85 (57.1) | 64 (43.0) | 0.0001 * |
| No | 1083 (74.4) | 142 (13.1) | 941 (86.9) | 367 (71.1) | 142 (38.7) | 225 (61.3) | ||
| CNS invasion intraoperatively not seen on histopathology | ||||||||
| Yes | 299 (20.6) | 59 (19.7) | 240 (80.3) | 0.0272 * | 113 (21.9) | 59 (52.2) | 54 (47.8) | 0.0464 * |
| No | 1156 (79.5) | 168 (14.5) | 988 (85.5) | 403 (78.1) | 168 (41.7) | 235 (58.3) | ||
| CNS invasion double positive (histopathology and intraoperatively) | ||||||||
| Yes | 46 (3.2) | 17 (37.0) | 29 (63.0) | <0.0001 * | 23 (4.5) | 17 (73.9) | 6 (26.1) | 0.0031 * |
| No | 1409 (96.8) | 210 (14.9) | 1199 (85.1) | 493 (95.5) | 210 (42.6) | 283 (57.4) | ||
| WHO classification 2007 | ||||||||
| I | 1313 (86.6) | 166 (12.6) | 1147 (87.4) | <0.0001 * | 437 (79.5) | 166 (38.0) | 271 (62.0) | <0.0001 * |
| II | 200 (13.2) | 74 (37) | 126 (63) | 110 (20.0) | 74 (67.3) | 36 (32.7) | ||
| III | 4 (0.3) | 2 (50) | 2 (50) | 3 (0.6) | 2 (66.7) | 1 (33.3) | ||
| WHO classification 2016 | ||||||||
| I | 1281 (84.4) | 158 (12.3) | 1123 (87.7) | <0.0001 * | 425 (77.3) | 158 (37.2) | 267 (62.8) | <0.0001 * |
| II | 232 (15.3) | 82 (35.3) | 150 (64.7) | 122 (22.2) | 82 (67.2) | 40 (32.8) | ||
| III | 4 (0.3) | 2 (50) | 2 (50) | 3 (0.56) | 2 (66.7) | 1 (33.3) | ||
Asterisk (*): statistically significant result.