Table 1.
Epigenetic drugs in clinical trials focused on breast cancer.
| Epi-Drug | Other Interventions | Status | Phase | Trial No. |
|---|---|---|---|---|
| Decitabine | LBH589, Tamoxifen | Terminated | 1, 2 | NCT01194908 |
| Paclitaxel | Unknown | 1b | NCT03282825 | |
| Carboplatin | Recruiting | 2 | NCT03295552 | |
| Doxorubicin and 4 more | Recruiting | 2 | NCT02957968 | |
| Azacitidine | Nab-paclitaxel | Completed | 1, 2 | NCT00748553 |
| Entinostat | Active, not recruiting | 2 | NCT01349959 | |
| Definitive breast | Withdrawn | NA | NCT01292083 | |
| Fulvestrant | Terminated | 2 | NCT02374099 | |
| Durvalumab | Active, not recruiting | 2 | NCT02811497 | |
| Valproic acid | FEC100 | Terminated | 2 | NCT01010854 |
| Hydralazine | Terminated | 2 | NCT00395655 | |
| Bevacizumab, Cetuximab | Recruiting | 1 | NCT01552434 | |
| Entinostat | Capecitabine | Recruiting | 1 | NCT03473639 |
| Exemestane | Recruiting Completed Active, not recruiting Active, not recruiting |
3 2 3 2 |
NCT03538171, NCT00676663, NCT02115282, NCT03291886 |
|
| Fulvestrant | Withdrawn | 2 | NCT02115594 | |
| Lapatinib Ditosylate, Trastuzumab | Completed | 1 | NCT01434303 | |
| Anastrozole | Terminated | 2 | NCT01234532 | |
| Nivolumab, Ipilimumab | Active, not recruiting | 1 | NCT02453620 | |
| Atezolizumab and 6 more | Recruiting | 1, 2 | NCT03280563 | |
| Romidepsin | Cisplatin, Nivolumab | Suspended | 1, 2 | NCT02393794 |
| Abraxane | Terminated | 1, 2 | NCT01938833 | |
| Alone | Completed | 2 | NCT00098397 | |
| Vorinostat | Olaparib | Not yet recruiting | 1 | NCT03742245 |
| Paclitaxel and 3 more | Completed | 1, 2 | NCT00574587 | |
| Alone | Completed Terminated Completed Withdrawn Completed Terminated |
1 2 2 NA 1 2 |
NCT00719875, NCT00132002, NCT00262834, NCT01695057, NCT00788112, NCT00126451 |
|
| Tamoxifen | Completed Terminated |
2 2 |
NCT00365599, NCT01194427 |
|
| Tamoxifen, Pembrolizumab | Terminated Not yet recruiting |
2 2 |
NCT02395627, NCT04190056 |
|
| Carboplatin, Nab-paclitaxel | Active, not recruiting | 2 | NCT00616967 | |
| Ixabepilone | Completed | 1 | NCT01084057 | |
| Lapatinib | Terminated | 1, 2 | NCT01118975 | |
| Paclitaxel, Bevacizumab | Completed | 1, 2 | NCT00368875 | |
| Anastrozole, Letrozole, Exemestane | Completed Completed |
NA NA |
NCT01720602, NCT01153672 |
|
| Trastuzumab | Completed | 1, 2 | NCT00258349 | |
| Belinostat | Ribociclib | Not yet recruiting | 1 | NCT04315233 |
| Panobinostat | Alone | Completed Terminated Withdrawn |
2 2 1 |
NCT00777049, NCT00777335, NCT00993642 |
| Trastuzumab | Terminated | 1, 2 | NCT00567879 | |
| Letrozole | Completed | 1, 2 | NCT01105312 | |
| Trastuzumab, Paclitaxel | Completed | 1 | NCT00788931 | |
| Capecitabine, Lapatinib | Completed | 1 | NCT00632489 |