Table 4.
In vivo studies in the treatment of UC using BMSCs.
| Method of UC Induction | Animal Model | Outcome | Reference |
|---|---|---|---|
| TNBS | Mice | Repair of injured intestinal mucosa. | [65] |
| TNBS | Rat | Healing in colonic lesions. | [66] |
| TNBS | Guinea-pig | Prevention of enteric neuropathic inflammation. | [67] |
| TNBS and DSS | Mice | Diminishing mucosal damage. | [68] |
| TNBS and DSS | Rat | Enhancement in the repair of an injured intestinal epithelium. | [37] |
| DSS | Rat | Ameliorating colonic lesions. | [69] |
| DSS | Rat | Repair of ulcerations. | [70] |
| DSS | Rat | Improvement in prompted colonic lesions. | [71] |
| DSS | Rat | Promoting the repair of colitis. | [72] |
| DSS | Mice | Preventive and fast recovery effects of mucosal damage. | [47] |
| DSS | Mice | Healing effects in colonic lesions. | [48] |
| DSS | Mice | Optimal mice colitis recovery. | [73] |
| DSS | Mice | Alleviation of colonic pathology. | [74] |
| DSS | Mice | Successful colonic mucosal regeneration. | [27] |
| DSS | Mice | Beneficial effects in healing of colonic lesions. | [75] |
| DSS | Mice | Attenuating UC. | [76] |
| DSS | Mice | No significant histopathologic or clinical improvement, limited therapeutic approach. | [77] |
| DSS | Mice | Promotion of tissue repair. | [78] |
| DSS | Mice | Reduction in intestinal inflammation. | [79] |
| DSS | Mice | Promoting healing effects in colonic lesions. | [80] |
| DSS | Mice | Enhancing repair in injured tissue. | [81] |
| DSS | Mice | Restoring intestinal mucosal permeability. | [82] |
| DSS | Mice | Sustained protection against acute inflammation in the long term. | [83] |
| Acetic acid | Rat | Ameliorating clinical manifestations and inflammation in UC. | [46] |
TNBS: Trinitrobenzene sulfonic acid; DSS: Dextran sulfate sodium-induced colitis; MSCs: Mesenchymal stem cells; BMSCs: Bone marrow-derived stem cells.