Table 3.

Virulence and heavy metal resistance-associated genes of MAR14-456.

Gene Cluster—Function	Location
Allantoinase cluster—Metabolism of allantoin: allA(1), allB(1), allC(2), allD(1), allR(1), allS(1), arcC(1), fdrA(1), gcl(2), glxK(1), glxR(1), hyi(1), ybbW(1), ybbY(1), ylbE(1), ylbF(1), KP1 1364(1), KP1 1371(1)	chromosome
Type III fimbrial gene cluster—Mannose-resistant Klebsiella-like (type III) fimbria production and biofilm formation: mrkA(1), mrkB(1), mrkC(1), mrkD(1), mrkF(1), mrkH(1), mrkI(2), mrkJ(1)	chromosome
Microcin E492 cluster—Bacteriocin production: mceA(1), mceB(1), mceC(1), mceD(2), mceE(1), mceG(2), mceH(1), mceI(2), mceJ(2)	chromosome
Colibactin cluster—Toxin production: clbA(2), clbB(2), clbC(2), clbD(2), clbE(2), clbF(2), clbG(2), clbH(3), clbI(2), clbJ(5 ins.), clbK(3), clbL(2), clbM(2), clbN(2), clbO(2), clbP(2), clbQ(2), clbR(2)	chromosome
Yersiniabactin cluster—Iron acquisition system: ybtA(2), ybtE(2), ybtP(2), ybtQ(2), ybtS(2), ybtU(2), ybtX(2), fyuA(2), irp1(6)	chromosome
Iron uptake cluster kfuABC—Iron acquisition system: kfuA(1), kfuB(1), kfuC(1)	chromosome
Aerobactin cluster—Iron acquisition system: iucA(1), iucB(1), iucC(1), iucD(1)	IncHI1B/FIB plasmid
Iron uptake (salmochelin) cluster iroBCDN—Iron acquisition system: iroB(1), iroC(4), iroD(1), iroN(1)	IncHI1B/FIB plasmid
rmpA/rmpA2—Regulators of mucoid phenotype: rmpA(2), rmpA2(8 frameshift)	IncHI1B/FIB plasmid
pbrABCR cluster—Lead resistance: pbrA(4), pbrBC(1), pbrR(1)	IncHI1B/FIB plasmid
pcoABCDERS cluster—Copper resistance: pcoA(1), pcoB(1), pcoC(1), pcoD(1), pcoE(4), pcoR(1), pcoS(1)	IncHI1B/FIB plasmid
silCERS cluster—Silver resistance: silC(1), silE(1), silR(1), silS(1)	IncHI1B/FIB plasmid
terABCDEWXYZ cluster—Tellurite resistance: terA(2), terB(2), terC(2), terD(2), terE(2), terW(2), terX(2), terY(2), terZ(2)	IncHI1B/FIB plasmid

Allele variants of the genes are shown in parentheses according to BIGSdb-Kp database nomenclature (https://bigsdb.pasteur.fr).