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. 2020 Dec 3;12(12):3626. doi: 10.3390/cancers12123626

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Inhibition of E2F4as could suppress proliferation and metastasis of ovarian cancer cells. (A) Expression of lncRNA E2F4as in six ovarian cancer cell lines and one human embryonic kidney cell line was detected by qRT-PCR. (B) CCK-8 assay used to detect proliferation ability of SKOV3 and OVCA429 cells. (C) Wound healing assay used to measure migration ability. Yellow colour line indicates width of the wound. (D) Cell invasion observed under optical microscope. Matrigel invasion assay used to determine invasion after 48 h of incubation of E2F4as knockdown SKOV3 and OVCA429 cells. Matrigel invasion assay results showing percentage of each cell line. Data expressed as mean ± standard deviation; *p < 0.05, **p < 0.01, *** p < 0.001 vs. siNC.