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. 2020 Dec 3;9(12):2591. doi: 10.3390/cells9122591

Figure 2.

Figure 2

Crosstalk between oncogenes, signaling pathways, and iron regulators. Red: upregulation reported in cancer. Blue: downregulation reported in cancer. Several oncogenic transcription factors, signaling pathways, and proto-oncogenes directly regulate key players of iron metabolism. Notably, TfR1 upregulation can be caused by activation of HIF1 and MYC overexpression of IRP2, or loss of wild-type p53 [51,155,184,185]. Similarly, ferritin (FT) decrease can result from activation of MYC, IRP2, or p53 mutation [51,155,185]. Such a vicious cycle is sustained as increased LIP promotes CDK, JAK/STAT, PI3K, MAPK/ERK pathways [172], whereas heme can further enhance ERK and MYC and inhibits p53 [181,186,187].