Table 2.
M. tuberculosis ABC transporters whose structure was solved. FHA-1 and FHA-2: Fork-Head Associated domains (1 and 2) from the Rv1747 transporter; SBP: substrate-binding protein; ECD: extracellular domain.
| Transporter Component | 3D Structure |
PDB | Ligand | Reference |
|---|---|---|---|---|
| Rv2318 (UspC) SBP type II, sugar |
|
5K2Y; 5K2X | - | [15] |
| Rv2833c (UgpB) SBP type II, sugar |
|
6R1B; 4MF1 |
GPC - |
[17] |
| Rv3666c (DppA) SBP type II, peptides |
|
6E4D | SSVT | [19] |
| Rv0411c (GlnH) SBP type II, amino acids |
|
6H20 6HIU 6H2T |
Asn Asp Glu |
[22] |
| Rv2400c (SubI) SBP type II, anion |
|
6DDN | SO4 | - |
| Rv0928 (PstS3) SBP type II, anion |
|
4LVQ | PO4 | [42] |
| Rv0934 (PstS1) SBP type II, anion |
|
1PC3 | PO4 | [43] |
| Rv0263c (FecB2) SBP type III, iron |
|
4PM4 | - | - |
| Rv1348/Rv1349 (IrtAB), full transporter, iron |
|
6TEJ; 6TEK | - - |
[30] |
| Rv1819c (BacA) Full transporter |
|
6TQF; 6TQE |
AMP-PNP | [32] |
| Rv1747_FHA-1 Lipooligosaccharides, drugs |
|
6CCD | - | [44] |
| Rv1747_FHA-2 Lipooligosaccharides, drugs |
|
6CAH | - | [44] |
| Rv3101 (FtsX) ECD, division |
|
4N8N 4N8O |
- | [45] |