. 2020 Dec 4;9(12):443. doi: 10.3390/biology9120443

Table 3.

Genomic context and structural organization of ATP- binding cassette (ABC) export systems in Mycobacterium tuberculosis. The ABC exporters are divided into four groups according to their function. Genes that belong to the genomic context are shown as arrows. The predicted number and structural organization of TM helices and structural organization according TOPCONS are shown in the last column, where transmembrane domains (TMDs) are colored in clear and dark green, nucleotide-binding domains (NBDs) in purple, and regulatory domains (when present) in pale purple. FHA is the fork-head associated domain and ECD is the extracellular domain.

EXPORTERS
ABC Systems/Genomic Organization	Genomic Organization	Structural Organization
Recycling of Membrane compounds/Liposaccharides
RfbD/RfbE (Rv3783/Rv3781)
[NBDr/TM/ECD]_(2x)
Cell wall biosynthesis,
ABC-2 subfamily of integral membrane proteins [9]
* Rv1747
[FHA_(2x)/NBD/TM]_(2x)
Lipo-oligosaccharides/drug efflux [83]
Electron transport chain (ETC)
CydC/CydD (Rv1620c/Rv1621c)
TM₁/NBD₁-TM₂/NBD₂
Cytochrome biosynthesis [84]
Virulence, adaptation
* Rv0987/Rv0986
Adhesion component
[ECD_2x/TM/NBD]_(2x)
[85]
FtsX/FtsE (Rv3101/Rv3102)
Cell division
[ECD/TM/NBD]_(2x)
[86]
Drug efflux
DrrC/DrrB/DrrA (Rv2938/37/36)
TM₁/TM₂-[NBD]_(2x)
Daunorubicin/doxorubicin [87]
Rv2686c/Rv2687c/Rv2688c
TM₁/TM₂-[NBD]_(2x)
Fluoroquinolones
[88]
Rv1686c/Rv1687c
[TM/NBD]_(2x)
Multidrug efflux [9]
Rv1273/Rv1272
[TM/NBD]_(2x)
MSBA subfamily/Drug efflux [87]
Rv1456c/Rv1457c/Rv1458c
Antibiotic transport
TM₁/TM₂-[NBD]_(2x) [89]
Rv0194
Drug efflux transport
[TM/NBD]_(2x) [90]
Rv1217c/Rv1218c
[TM/NBD]_(2x) [91]
Rv1473
NBD
Macrolides efflux [92,93]
Rv2477c
NBD
Macrolides efflux [93]