Table 1.
Treatment option for pharyngitis in the different periods in the three Centers.
| Center A | Center B | Center C | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Period | Pre | Post 1 | Post 2 | Post 3 | p-Value | Pre | Post 1 | Post 2 | p-Value | Pre | Post 1 | Post 2 | Post 3 | p-Value |
| 298 | 364 | 326 | 264 | 290 | 241 | 251 | 363 | 217 | 316 | 319 | ||||
| No antibiotic, N (%) | 147 (49.3) | 198 (54.4) | 120 (36.8) | 129 (48.9) | <0.001 | 135 (46.6) | 140 (58.1) | 122 (48.6) | 0.021 | 23 (6.3) | 15 (6.9) | 44 (13.9) | 23 (7.2) | 0.002 |
| Antibiotic therapy, N (%) | 151 (50.7) | 166 (45.6) | 206 (63.2) | 135 (51.1) | 155 (53.4) | 101 (41.9) | 129 (51.4) | 340 (93.7) | 202 (93.1) | 272 (86.1) | 296 (92.8) | |||
| Amoxicillin, N (%) | 81 (53.6) | 155 (93.4) | 192 (93.2) | 133 (98.5) | <0.001 | 108 (69.7) | 97 (96.0) | 114 (88.4) | <0.001 | 42 (12.4) | 144 (71.3) | 133 (48.9) | 84 (28.4) | <0.001 |
| Broad spectrum, N (%) | 70 (46.4) | 11 (6.6) | 14 (6.8) | 2 (1.5) | 47 (30.3) | 4 (4.0) | 15 (11.6) | 298 (87.6) | 58 (28.7) | 139 (51.1) | 212 (71.6) | |||
| Co-amoxiclav, N (%) | 60 (39.7) | 5 (3.0) | 9 (4.4) | 1 (0.7) | <0.001 | 28 (18.1) | 1 (1.0) | 5 (3.9) | <0.001 | 249 (73.2) | 45 (22.3) | 102 (37.5) | 170 (57.4) | <0.001 |
| Cephalosporins, N (%) | 10 (6.6) | 6 (3.6) | 4 (1.9) | 1 (0.7) | 0.029 | 14 (9.0) | 3 (3.0) | 7 (5.4) | 0.131 | 17 (5.0) | 4 (2.0) | 25 (9.2) | 33 (11.1) | <0.001 |
| Macrolides, N (%) | 0 (0.0) | 0 (0.0) | 1 (0.5) | 0 (0.0) | 5 (3.2) | 0 (0.0) | 3 (2.3) | 0.203 | 32 (9.4) | 9 (4.5) | 12 (4.4) | 9 (3.0) | 0.004 | |
| Amoxicillin dosage, Median [IQR], mg/kg/die | 50.0 [0.0] | 50.0 [0.0] | 50.0 [1.0] | 50.0 [0.0] | 0.288 | 53.7 [7.0] | 50.6 [3.5] | 51.6 [3.8] | <0.001 | / | / | / | / | / |
| Days of therapy, Median [IQR] | 8.0 [3.0] | 10.0 [0.0] | 10.0 [0.0] | 10.0 [0.0] | <0.001 | 10.0 [1.0] | 10.0 [0.0] | 10.0 [0.0] | 0.622 | 7.0 [0.0] | 7.0 [3.0] | 8.00 [1.0] | 7.0 [1.0] | <0.001 |
IQR = Interquartile range.