Table 3.

Inhibition of LTD4-induced IP1 production by BRI-12359.

	CysLT1R-WT			CysLT2R-WT
[BRI-12359] μM	LTD4 EC50 ± SEM nM	LTD4 Emax ± SEM%	pA2 ± SEM −log	LTD4 EC50 ± SEM nM	LTD4 Emax ± SEM %	pA2 ± SEM −log
0	3.3 ± 0.3	100 ± 6	6.5 ± 0.1	30 ± 3	100 ± 3	4.0 ± 0.2
1	8 ± 1	84 ± 9		24 ± 2	101 ± 3
10	14 ± 2	83 ± 9		31 ± 3	99 ± 3
30	19 ± 4	64 ± 12		43 ± 6	93 ± 10
60	29 ± 8	41 ± 13		45 ± 8	70 ± 16
100	15 ± 4	35 ± 8		50 ± 8	64 ± 13