ACT	Adoptive cell-based therapy
ADCC	Antibody-dependent cellular cytotoxicity
BiTEs	Bispecific T-cell engagers
CAR	Chimeric antigen receptor
CBL-B	Casitas B-lineage lymphoma proto-oncogene-B
CISH	Cytokine inducible SH2 containing protein
COVERT	Cytoplasmic oncoprotein verifier and response trigger
CRS	Cytokine release syndrome
CTLA-4	Cytotoxic T-lymphocyte antigen 4
dCas9	Dead CRISPR associated protein 9
DGK	Diacylglycerol kinase
EGFR	Epidermal growth factor receptor
EpoR	Erythropoietin receptor
GEARs	Generalized engineered activation regulators
GEMS	Generalized extracellular molecules sensors
GM-CSF	Granulocyte-macrophage colony stimulating factor
GPCRs	G protein-coupled receptors
GrzB	Granzime B
HIF-1α	Hypoxia-inducible factor-1α
iCAR	Inactivating CAR
ICOS	Inducible T cell co-stimulator
IDO-1	Indoleamine 2,3-dioxygenase 1
IFN	Interferon
irAEs	Immune-related adverse events
ITAM	Immunoreceptor tyrosine-based activation motif
ITIM	Immunoreceptor tyrosine-based inhibitory motif
JAK/STAT	Janus kinase/signal transducer and activator of transcription
LAG-3	Lymphocyte-activation gene-3
LOH	Loss of heterozygosity
MAPK	Mitogen-activated protein kinase
MCP	MS2 bacteriophage coat protein
MDSC	Myeloid-derived suppressor cells
MHC	Major histocompatibility complex
MRSA	Methicillin resistant Staphylococcus aureus
NR4A	Nuclear receptor 4 A
PD-1/PD-L1	Programmed cell death protein-1/Programmed cell death protein-ligand 1
PI3K/Akt	Phosphatidylinositol 3-kinase/Protein kinase B
PLC-γ	Phospholipase C gamma
PSMA	Prostate-specific membrane antigen
PTPN22	Protein tyrosine phosphatase, non-receptor type 22
RASAL1	RAS protein activator like 1
sCARs	Switchable CAR-T-cells
scFv	Single chain variable fragment of an antibody
SENP1	Sentrin-specific protease 1
sgRNA	Synthetic guide RNA
SHP1	Src homology 2 domain-containing protein tyrosine phosphatase 1
SOCS1	Suppressor of cytokine signaling 1
SUMO	Small ubiquitin-like modifier
SUPRA CAR	Split universal programmable CAR
SynNotch	Synthetic Notch
TAAs	Tumor-associated antigens
TCE	T cell exhaustion
TCM	T central memory
TCR	T cell receptor
TEV	Tobacco etch virus
TGFβ	Transforming growth factor beta
TGFβRII	Transforming growth factor beta receptor 2
TIGIT	T cell immunoreceptor with Ig and ITIM domains
TILs	Tumor infiltrating lymphocytes
TIM-3	T-cell immunoglobulin and mucin domain-3
TLRs	Toll-like receptors
TME	Tumor microenvironment
TNFR	Tumor necrosis factor receptor
TOX	Thymocyte selection-associated high mobility group box protein
TRUCKs	T cells redirected for universal cytokine-mediated killing
VEGF	Vascular endothelial growth factor