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. 2020 Dec 4;9(12):2592. doi: 10.3390/cells9122592

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Correlation between the percentage of resting CD4⁺CD28⁻ cells and clinical, radiological, and analytical variables in EA patients. (a) Percentage of CD4⁺CD28⁻ cells according to initial diagnosis is shown. Graph box represents n = 4 patients with rheumatoid arthritis (RA) and n= 8 patients with undifferentiated arthritis (UA). Statistical significance was determined with Mann–Whitney test. Significance threshold was set at p < 0.05. (b) Logarithmic transformation of the percentage of CD4⁺CD28⁻ cells according to the degree of disease activity is shown. The activity of the disease in EA patients at baseline was classified according to 28-joint disease activity score (DAS28) into remission (<2.5), low activity (2.5–5.0), moderate activity (5.0–7.5), and high activity (7.5–10). Correlation between the percentage of these cells and DAS28 (c) and erythrocyte sedimentation rate (ESR) (d) was determined by the use of Pearson’s coefficient test. Data from 20 EA patients at baseline were analyzed.