Table 1.
Characteristics of donors and baseline early arthritis.
| Non-EA Donors | EA Patients | Normal Range | ||
|---|---|---|---|---|
| Baseline | 6 Months | Normal Range | ||
| Number | 13 | 25 | ||
| Age (years) | 65.5 ± 16.5 | 51.6 ± 15.0 * | ||
| Female gender, n (%) | 5 (39%) | 19 (76%) | ||
| ACPA + (%) | n.d. | 45 | Negative: <20 U Grey zone: 20–39 U Positive: ≥40 U |
|
| RF + (%) | n.d. | 52 | 0–14 U/mL | |
| BMI | 26.2 ± 3.57 | 26.4 ± 3.84 | ||
| DAS28 | n.d. | 3.92 ± 1.63 | 2.77 ± 1.35 #p = 0.016 | |
| HUPI | n.d. | 5.38 ± 3.50 | 3.49 ± 2.87 p= 0.06 | |
| ESR (mm/h) | n.d. | 28.6 ± 19.4 | 21.2 ± 18.2 | 0–25 U |
| CRP (mg/dL) | n.d. | 0.57 ± 0.53 | 0.29 ± 0.24 p= 0.059 | 0–0.5 mg/dL |
| AP (U/L) | n.d. | 72.8 ± 16.1 | 71.6 ± 18.5 | 35–105 U/L |
| β-Crosslap (β-CTX) | n.d. | 387 ± 133 | 379 ± 107 | Pr.W. 137–573 pg/mL Po.W. 226–1008 pg/mL Men 30–50 y.o. 142–584 pg/mL Men 50–70 y.o. 200–704 pg/mL Men > 70 y.o. 230–854 pg/mL |
Data are shown as the median ± standard deviation or n (%). ACPA: anticitrullinated peptide antibodies; RF: Rheumatoid factor; BMI: Body Mass Index; DAS28: 28-joint disease activity score; HUPI: Hospital Universitario Princesa Index; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; AP: alkaline phosphatase. n.d.: non determined; Pr.W.: premenopausal women; Po.W.: postmenopausal women; y.o.: years old. The asterisk character (*) shows the significant differences between non-EA donors and EA patients (p > 0.05), and pad character (#) shows the significant differences between EA-patients baseline and EA-patients after 6 months.