Schematic representation of the general polyphenol biosynthetic pathway, with the main classes of polyphenols. PAL, Phenylalanine ammonia lyase; C4H, cinnamic acid 4-hydroxylase; C3H, p-coumarate 3-hydroxylase; HCT, hydroxycinnamoyl CoA shikimate/quinate hydroxycinnamoyl transferase; HQT, hydroxycinnamoyl CoA quinate hydroxycinnamoyl transferase; 4CL, 4-coumarate:coenzyme A ligase; STS, stilbene synthase; CHS, chalcone synthase; CHI, chalcone isomerase; IFS, isoflavone synthase; FNS, flavone synthase; F3H, flavanone-3-hydroxylase; FLS, flavonol synthase; DFR, dihydroflavonol reductase; LAR, leucoanthocyanidin reductase; ANS, anthocyanidin synthase; ARS, anthocyanidin reductase; GTs, glycosyltransferases.