Table 1.
Summary of patients on high dose (≥ 4 mg/kg/day) disulfiram (n = 33).
| Patient ID | M/F | Age | Weight (kg) | Max Dose (mg/kg/day) | Duration | Infection & Other Conditions | Other Rx | Adverse Reaction | Benefit |
|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 29 | 95 | 5.3 | 6 WK | Bb | Psych | Y E | |
| 2 | F | 24 | 57 | 5.5 | 5 MO | Bb, Bh | PN, FAT | Y | |
| 3 | F | 61 | 71 | 7 7 |
6 WK 4 WK |
Bb | PN, Psych, syncope | Y Y E |
|
| 4 | F | 64 | 82 | 4.6 | 5 MO | Bb | FAT, Psych, Arth, LFT | Y | |
| 5 | M | 59 | 64 | 5.8 | 6 WK | Bb, Bm | FAT | Y | |
| 6 | M | 29 | 65 | 7.7 | 5 MO | Bb, CRPS | PN, FAT, Arth | Y | |
| 7 | F | 27 | 106 | 7.1 9.4 |
6 WK 9 WK |
Bb, Bd | PN, FAT, Arth | Y Y E |
|
| 8 | F | 62 | 60 | 8 | 11 WK | Bb | FAT, Psych, LFT, near syncope | Y E | |
| 9 | F | 63 | 70 | 5.4 | 3 MO | Bb, Bm | FAT, hyperdynamic | Y | |
| 10 | M | 59 | 100 | 3.3 5.0 |
4 MO 3 MO |
Bb, Bm | FAT | Y Y E |
|
| 11 | M | 50 | 88 | 5.7 5.7 |
6 WK 12 WK |
Bb, RMSF | FAT | Y E Y E |
|
| 12 | F | 66 | 54 | 9.3 | 14 WK | Bb, Bm | PN, FAT, Psych | Y E | |
| 13 | M | 70 | 73 | 6.8 | 3 MO | Bb | PN, FAT, Psych | Y | |
| 15 | F | 55 | 60 | 4.1 | 2 MO | Bb, Bm | PN, FAT, LFT | Y E | |
| 16 | M | 21 | 60 | 8.3 | 12 WK | Bb, Bm, Bh | Psych, FAT, LFT | Y E | |
| 17 | M | 52 | 103 | 7.3 | 10 WK | Bb, Bm | Psych | Y | |
| 18 | M | 50 | 93 | 5.4 | 3 MO | Bb, Bm | Psych | Y E | |
| 19 | F | 46 | 55 | 6.8 | 10 WK | Bb, Bh | azith, rifam | FAT | Y |
| 20 | F | 34 | 60 | 6.25 | 6 MO | Bb, OCD | FAT, Psych | unclear | |
| 21 | F | 62 | 75 | 6.7 6.7 |
6 WK 3 MO |
Bb, Bh | FAT | Y Y E |
|
| 22 | M | 28 | 59 | 6.4 | 6 WK | Bb, Bh, Imm Def | N | ||
| 23 | F | 63 | 34 | 7.1 3.6 |
2 MO 4 MO |
Bb | FAT, PN Psych | Y Y |
|
| 24 | F | 48 | 64 | 4.9 | 8 MO | Bb, Bm, POTS | Psych, FAT, Arth | Y | |
| 29 | F | 23 | 59 | 5.3 | 6 MO | Bb | FAT, Psych after d/c | Y | |
| 34 | F | 51 | 59 | 6.4 | 7 WK | Bb | FAT, Arth | Y | |
| 36 | F | 18 | 77 | 4.8 | 7 MO+ | Bb | PN | Y | |
| 37 | F | 74 | 115 | 6.5 6.5 |
6 WK 3 MO+ (alt. mos. on & off) |
Bb | Y Y |
||
| 38 | M | 71 | 95 | 5.3 | 4 MO | Bb | LFT | Y | |
| 39 | F | 59 | 63 | 6 2 |
5 MO 4 MO+ |
Bb, Bh | azith+, rifam | FAT, Arth, Psych | N Y |
| 42 | M | 25 | 92 | 5.4 | 4 MO | Bb, Bd, TBRF | Psych | Y | |
| 49 | M | 83 | 76 | 5.8 1.6 |
6 WK 2 MO+ |
Bb, Bm, myopathy |
syncope | Y E Y re-bitten |
|
| 50 | F | 37 | 66 | 7.5 3.8 0.6 0.6 |
6 WK 3 WK 2 WK 3 MO+ |
Bb, Bm | Psych, FAT | N N Y Y |
|
| 54 | M | 73 | 85 | 4.4 | 4 MO+ | Bb, Bm, Bh | mino, rifam | Y re-bitten |