Table 1.

Nutrient preference reported in Randle cycle abiding and non-abiding tumors and their response to environmental stress and metastasis.

	Tumor Type	Primary (Warburg Effect)	Metastasis/Environmental Stress	Reference
Randle Cycle	Colorectal cancer	High glycolysis to lactate Dependent on glucose and glutamine to proliferate. Glucose and glutamine used for FA synthesis.	FAO is elevated as an acidic stress response. FAO is needed to survive detachment and the metastatic process.	[21,22,23,27]
	Glioblastoma	High glycolysis to lactate Dependent on glucose and glutamine to proliferate. Glucose and glutamine used for FA synthesis.	FAO is recruited to survive stresses imposed by the microenvironment. FAO is recruited to protect from oxidative stress (elevated ROS).	[16,28,29,30]
	Tumor Type	Primary (Non-Solid Tumors)	Metastasis/Environmental Stress	Reference
Non-Randle Cycle	Lymphomas/ Leukemias	High glycolysis to lactate Dependent on glucose and glutamine to proliferate. FAO needed to meet ATP demand and counteract high ROS production caused by growth in suspension.	The primary tumor already show a shift in nutrient preference similar to solid tumors when they are detaching and metastasizing. FAO is not a defining feature of all non-solid tumors, as a subset of B-cell lymphoma are Warburg-like and do not recruit FAO.	[25,26,31]