Table 2.

Univariate and multivariable linear regression models for lipid profiles as dependent variables in prepubertal children.

	TC (mg/dL)			HDL-C (mg/dL)			LDL-C (mg/dL)			Triglycerides (mg/dL)			Non-HDL-C (mg/dL)			AIP
	Beta	R2	p Value	Beta	R2	p Value	Beta	R2	p Value	Beta	R2	p Value	Beta	R2	p Value	Beta	R2	p Value
Univariate linear regression with SHBG and BMI SDS on lipid profiles in prepubertal children
Total (n = 693)
SHBG	−0.005	<0.001	0.855	0.075	0.068	<0.001	−0.008	<0.001	0.763	−0.358	0.045	<0.001	−0.080	0.014	0.002	−0.002	0.064	<0.001
BMI SDS	4.254	0.032	<0.001	−1.747	0.034	<0.001	3.819	0.030	<0.001	10.816	0.037	<0.001	5.995	0.072	<0.001	0.056	0.054	<0.001
Boys (n = 145)
SHBG	−0.061	0.006	0.335	0.118	0.141	<0.001	−0.077	0.012	0.186	−0.511	0.065	0.002	−0.179	0.060	0.003	−0.002	0.103	<0.001
BMI SDS	6.295	0.065	0.002	−2.076	0.041	0.014	5.586	0.061	0.003	13.845	0.046	0.010	8.355	0.124	<0.001	0.061	0.060	0.003
Girls (n = 548)
SHBG	0.010	<0.001	0.740	0.065	0.053	<0.001	0.005	<0.001	0.851	−0.298	0.035	<0.001	−0.055	0.007	0.053	−0.002	0.052	<0.001
BMI SDS	3.863	0.026	<0.001	−1.816	0.036	<0.001	3.845	0.029	<0.001	9.081	0.029	<0.001	5.677	0.064	<0.001	0.053	0.049	<0.001
Multivariable linear regression models for lipid profiles as dependent variables after adjusting for BMI SDS
Total (n = 693)
SHBG	0.075	0.040	0.014	0.051	0.063	<0.001	0.064	0.036	0.027	−0.260	0.055	<0.001	0.011	0.072	0.692	−0.001	0.080	<0.001
Boys (n = 145)
SHBG	0.076	0.071	0.315	0.122	0.142	<0.001	0.034	0.063	0.621	−0.398	0.072	0.047	−0.045	0.127	0.520	−0.002	0.108	0.006
Girls (n = 548)
SHBG	0.078	0.035	0.022	0.065	0.072	<0.001	0.071	0.038	0.024	−0.221	0.044	0.003	0.026	0.065	0.398	−0.001	0.070	<0.001

SHBG: sex hormone-binding globulin; BMI: body mass index; SDS: standard deviation score; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; AIP: atherogenic index of plasma.