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. 2020 Dec 4;8(12):569. doi: 10.3390/biomedicines8120569

Table 3.

Anti-proliferative Activity of 6-Substituted-imidazo[1,2-a]pyridine Derivatives 3a–d.

EC50 (nM a)
N R P4E6 PC3 LNCaP PNT2-C2 BPH1
3a H 60.72 239.4 314.8 422.6 113.0
3b 4-F 4.038 70.92 240.0 217.0 41.47
3c 4-Cl 33.39 321.9 323.1 324.7 416.0
3d 3-CN 439.6 n.t. b 7180.0 1718.0 351.0

a EC50 values represent the concentration required to obtain half-maximal response. b Not tested.