Table 1.

Drugs approved as anti-cancer compounds and derived from marine compounds. Approved indications as assessed using http://adisinsight.springer.com/ in October 2020.

Compound	Marine Organism	Chemical Classes	Therapeutic Use	Ref.
Lurbinectedin	Tunicate	Alkaloid	Solid tumors	[32]
Trabectedin	Tunicate	Alkaloid	Solid tumors	[33]
Midostaurin	Tunicate/Actinobacteria	Indolocarbazole	Leukemias	[34]
Plitidepsin ^	Tunicate	Peptide	Multiple myeloma	[35]
Belantamab mafodotin	Mollusk/Cyanobacteria	ADC/Peptide **	Multiple myeloma	[36]
Enfortumab vedotin	Mollusk/Cyanobacteria	ADC/Peptide *	Solid tumors	[37]
Polatuzumab vedotin	Mollusk/Cyanobacteria	ADC/Peptide *	Lymphomas	[38]
Brentuximab vedotin	Mollusk/Cyanobacteria	ADC/Peptide *	Lymphomas	[39]
Eribulin mesylate	Sponge	Macrolide polyketide	Solid tumors	[40]
Fludarabine phosphate	Sponge	Nucleoside	Leukemias, lymphomas	[41]
Cytarabine	Sponge	Nucleoside	Leukemias, lymphomas	[42]
Nelarabine	Sponge	Nucleoside	Leukemias, lymphomas	[43]

ADC, antibody drug conjugate; ^, approved by the Australian Therapeutic Goods Administration; *, monomethyl auristatin E (MMAE) as payload; **, monomethyl auristatin F (MMAF).