Table 2.

ADCs containing MMAE or MMAF as payloads in clinical trials. Data assessed on https://clinicaltrials.gov (recruiting or active/not recruiting) in October 2020. Sorted by payload and by clinical status.

Clinical Status	Compound	Target	Payload	Marine Organism	Therapeutic Use	FDA Orphan Drug Designation	Ref.
Phase I	ALT-P7	HER2	MMAE	Mollusk/Cyanobacteria	Solid tumors	Gastric cancer	[44]
Phase I	RC88	Mesothelin	MMAE	Mollusk/Cyanobacteria	Solid tumors	-	*
Phase I	SGN-CD228A	CD228	MMAE	Mollusk/Cyanobacteria	Solid tumors	-	[45]
Phase II	CX-2029	CD71	MMAE	Mollusk/Cyanobacteria	Solid tumors, lymphomas	-	[46]
Phase II	Disitamab vedotin	HER2	MMAE	Mollusk/Cyanobacteria	Solid tumors	Gastric cancer	[47]
Phase II	Enapotamab vedotin	AXL	MMAE	Mollusk/Cyanobacteria	Solid tumors	-	[48]
Phase II	Ladiratuzumab vedotin	LIV-1 A	MMAE	Mollusk/Cyanobacteria	Solid tumors	-	[49]
Phase II	Telisotuzumab vedotin	MET	MMAE	Mollusk/Cyanobacteria	Solid tumors	-	[50]
Phase II	Tisotumab vedotin	TF	MMAE	Mollusk/Cyanobacteria	Solid tumors	-	[51]
Phase I	FS-1502	HER2	MMAF	Mollusk/Cyanobacteria	Solid tumors		[52]
Phase II	AGS 16C3F	ENPP3	MMAF	Mollusk/Cyanobacteria	Solid tumors	-	[53]
Phase III	Depatuxizumab mafodotin	EGFR	MMAF	Mollusk/Cyanobacteria	Solid tumors	Glioblastoma	[54]

FDA, Food and Drug Administration; MMAE monomethyl auristatin E; MMAF, monomethyl auristatin F; *, www.cancer.gov.