Table 3.

Molecules modulating the activity of TRPM4 and TRPM5, participation in physiological processes and pathologies.

Channel	Modulator	Inhibition or Activation 1	Function	Disease, Affection or Objective of Study 2	Model of Study	Ref.
TRPM4	PLC > PIP2 > IP3 > Ca2+ rise	+	Channel activation	PC	293T, HEK 293 and rosetta cells	[41,228,230,232,237]
	ATP PKC	- +	Ca2+ sensitivity	PC	HEK 293 cells	[228]
	ADP, ATP, AMP and adenosine	-	Channel activation	PC	HEK 293 cells	[232,238]
	CAM	-	Ca2+ sensitivity, activation and shift the voltage dependence of activation	PC	HEK293 cells	[235]
	Heat	+	Temperature- dependent activation curve	Thermal sensitivity of sweet taste	HEK293 cells	[241]
	Flufenamic acid and spermine	-	Channel activation	PC	HEK 293 cells	[232,243]
	9-phenanthrol	-	Channel activity	PC	HEK293 cells	[244,245]
	Glibenclamide	-	Channel current	PC	HEK293 cells	[246]
	CBA	-	Channel current	PC	HEK293 cells	[246,247]
TRPM5	PLC > PIP2 > Ca2+ rise	+ -	Channel activation, desensitization and sensibilization	PC	CHO-K1 or HEK-293 M1, 293T cells	[41,230,232,236]
	ATP	+	Channel activation	PC	293T cells	[41,230]
	Heat	+	Temperature- dependent activation curve	Thermal sensitivity of sweet taste	HEK293 cells	[241]
	pH 6.2–5.9	-	Channel activation	Taste transduction	HEK293 cells	[242]
	Flufenamic acid and spermine	-	Channel activation	PC	HEK 293 cells	[232,243]

¹: activation (+) and inhibition (-); ²: physiological conditions (PC).