Figure 4.

Impact of disease severity on kinetics of antibody responses against SARS-CoV-2. Comparison of neutralizing titer (IC₅₀) and OD values of S1-IgG, N-IgG, S1-IgM, and N-IgM for (a) individuals from the different disease severity categories; (b) individuals who survived or died; and (c) individuals who required ICU admission or not. Data are shown based on time post disease onset. Statistical significance was determined using one-way analysis of variance with Tukey post-hoc test in (a) and using Student’s t test in (b) and (c). Mean with SD are shown, and statistical significance is represented as *, p ≤ 0.05; **, p ≤ 0.01; and ****, p ≤ 0.0001.