Figure 5.

SP141 inhibits neuroblastoma xenograft tumor growth in vivo, without observable toxicity in the animals. Nude mice bearing NB-1643 or LA1-55n xenograft tumors were treated with SP141, which was administered by i.p. injection at 40 mg/kg/day, 5 d/week for 15 and 21 days, respectively. At the termination of the experiments, H&E staining was performed on paraffin-embedded sections of major organs (kidneys, heart, liver, brain, and lungs) from mice bearing NB-1643 and LA1-55n xenograft tumors (scale bar, 20 μm).