. 2020 Dec 4;9(12):3939. doi: 10.3390/jcm9123939

Table 1.

Overview of the differentially expressed miRNAs analyzed in muscle biopsies.

Study	miRNAs		Muscle Biopsy	Sample Size	Normalization	Targets	Associated Pathological Signs and Mechanisms
Gambardella 2010 [48]	miR-206	↑	Vastus lateralis	7 DM1 4 ctrls	Hsa-let-7a
Perbellini 2011 [51]	miR-1 * miR-29b/c ** miR-335 miR-33	↑ ↓ ↑ ↑	Biceps branchi	15 DM1 14 ctrls	miR-16	MEF2a ^,1 MET ^,1 GATA6 ^,1 HAND2 ^,1	muscle development ¹
						KCNE1 ^,2 KCNJ2 ^,2 CALM2 *^,2	Arrhythmia ²
						SFRS9 *^,3	Splicing ³
						DAG1 ^,4 DIABLO ^,4 RET TRIM63 ^,4 TGFB3 **^,4	Atrophy ⁴
Fernandez-Costa 2012 [52]	miR-1 * miR-7 miR-10 ***	↓ ↓ ↓	Vastus lateralis Biceps branchi Deltoid	5 DM1 3 ctrls	Sno-RNA RNU48	SOD1 *^,5 SMARCA4 ^,6 NET 1 ^,7 CTSB ^,8 ATG4 ^,9 VCL ^,10 UBE11 ***^,11	Free radical removal ⁵ Transcription ⁶ Apoptosis and signal transduction ⁷ Proteolysis ⁸ Autophagy ⁹ Cytoskeleton ¹⁰ Protein localization/activity regulation ¹¹
Fritegotto 2017 [53]	miR-1 miR-133a/b miR206	↓ ↓ ↑	Vastus lateralis	12 DM1 6 ctrls	Hsa-let-7a
Ambrose 2017 [52]	miR-1 miR-133a miR-29c	↓ ↓ ↓	Biceps branchi Gastrocnemius Deltoid	9 DM1 9 ctrls	Hsa-let-7a

↑ = upregulation, ↓ = downregulation, DM1 = DM1 patients, ctrls = healthy subjects, colors indicate to which miRNA the targets belong. Normalization stands for the miRNA, either endogenous or spike-in, that has been used to normalize the differentially expressed miRNAs. *, **, ***, ****, *****, indicate to which miRNA the targets belong. ^1–11 numbers indicates which Associated Pathological Signs and Mechanisms belong to which target.