Table 2.

Overview of the differentially expressed miRNAs analyzed in heart biopsies.

Study	miRNAs		Heart	Sample Size	Normalization	Targets	Associated Pathological Signs
Rau 2011 [55]	miR-1	↓	Left ventricle	5 DM1 8 ctrls	U6 snRNA	CACNA1C 1 GJA1 2	Arrhythmias 1 Conduction 2
Kalsotra 2014 [56]	miR-1 * miR-133 ** miR-30b ** miR-29b ** miR-145 let-7g miR-26a miR-328 miR-23a miR-23b miR365 miR-499 miR-125b miR-148a miR-194 let-7d miR-27a miR-22 miR-100	↓ ↓ ↓ ↓ ↓ ↓ ↓ ↓ ↓ ↓ ↓ ↓ ↓ ↓ ↓ ↓ ↓ ↓ ↓	unknown	8 DM1 4 ctrls	MammU6		Conduction * Fibrosis **

↑ = upregulation, ↓ = downregulation, DM1 = DM1 patients, ctrls = healthy subjects, colors indicate to which miRNA the proposed disease involvement belongs. Normalization stands for the miRNA, either endogenous or spike-in, that has been used to normalize the differentially expressed miRNAs. *, ** indicate to which miRNA the associated pathological signs belong. ^1,2 numbers indicates which Associated Pathological Signs belong to which target.