Figure 4.

Chronic stress increases l-type calcium currents at CA1 pyramidal neurons: Representative whole-cell endogenous l-type Ca²⁺ current traces from pyramidal neurons of CA1 of hippocampal slices from control (A) or subjected to CRS protocol (B) animals. Currents elicited by a voltage step protocol from −70 to 0 in 10 mV increments, V_h = −80 mV. (C) Summary peak current I/V plots (mean ± sem) obtained from currents family, as shown in (A, black circles) and (B, white circles), where the black line represents the best fit to a Boltzmann equation. (D) Bar graph (mean ± sem) of the mean l-type current obtained at −20 mV (n = 7); black bars represent control animals, and gray bars CRS-subjected animals, * p value < 0.05.