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. 2020 Dec 4;10(12):2303. doi: 10.3390/ani10122303

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Liver-to-body weight ratio (LBW) (A) and levels of hepatic free cholesterol (B) cholesteryl ester (C) and triacylglycerol (D). LBW in ApoE^–/– mice fed with HFD was significantly increased (i.e., 2.47%) compared to ApoE^–/– mice fed with HFD + APH (i.e., 2.01%) (p < 0.0001). No statistical difference was found in either hepatic free cholesterol (B) or cholesteryl ester (C), whereas hepatic triacylglycerol (D) content was significantly reduced in ApoE^–/– mice fed HFD+APH (214.39 ± 29.67 nmol/mg) compared to values obtained from ApoE^–/– control mice fed HFD (365.97 ± 46.20 nmol/mg). Data are presented as mean ± SD for n = 6 mice per group. Abbreviations: HFD, high-fat diet, APH, anchovy protein hydrolysates.