Table 3.

MiRNAs implicated in multiple cancers.

miRNA	Cancer/Disease Involvement	References
miR-15b miR-16	Upregulated in gastric cancer and downregulated in chronic lymphocytic leukemia (CLL)	Xia et al., 2008 [79] Cimmino et al., 2005 [80] Xia et al., 2008 [79]
LET-7	Downregulated in lung, pancreatic cancer and acute lymphoblastic leukemia (ALL)	Takamizawa et al., 2004 [81] Kugel et al., 2016 [82]
miR-34 (a, b and c)	Downregulated in gastric and cervical cancer neuroblastoma. Upregulated in glioblastoma multiforme (GBM) (miR-34b) and colorectal cancer (miR-34a)	Zhang and Liao, 2019 [83] He et al., 2009 [84], Hermeking et al., 2012 [85] Bommer et al., 2007 [86] Tarasov et al., 2007 [87] He et al., 2009 [84] Hasakova et al., 2019 [88] Han et al., 2002 [89]
miR-21	Upregulated in GBM, solid tumors and multiple myeloma	Kumarswamy et al., 2011 [90] Asangani et al., 2008 [91] Wang et al., 2019 [92] Jesionek-Kupnicka et al., 2019 [93] Pfeffer et al., 2015 [94]
miR-125 (a and b)	Upregulated in AML and GBM (miR-125b)	Bousquet et al., 2010 [95] Chaudhuri et al., 2012 [96] Wu et al., 2013 [97] Romero et al., 2015 [98] Liu et al., 2017 [99] Jesionek-Kupnicka et al., 2019 [93]
miR-181d	Downregulated in GBM	Zhang et al., 2012 [100] Yang et al., 2018 [101] Jesionek-Kupnicka et al., 2019 [93]
miR-648	Downregulated in GBM	Kreth et al., 2013 [102] Jesionek-Kupnicka et al., 2019 [93]
miR-155	Upregulated in AML, colorectal cancer and Hodgkin’s lymphoma	Fabbri et al., 2008 [103] Narayan et al., 2017 [104] Witten and Slack, 2020 [105] Kluiver et al., 2005 [106] Narayan et al., 2018 [107] Eis et al., 2005 [108]
miR-221	Upregulated in GBM	Lukiw et al., 2009 [109]
miR-30a-5p	Downregulated in colorectal cancer	Wei et al., 2016 [110]
miR-29 family	Upregulated in colorectal and cervical cancer and downregulated in lung cancer and AML	Fabbri et al., 2007 [44] Jiang et al., 2014 [111]
miR-145	Downregulated in colorectal cancer	Michael et al., 2003 [112] Sheng et al., 2017 [113]
miR-128a	Upregulated in AML	De Luca et al., 2017 [114]
miR-17/92 cluster	Upregulated and downregulated in myeloid leukemias and upregulated in colorectal cancer and CLL	Fabbri et al., 2008 [103] Jiang et al., 2011 [115] Moussay et al., 2011 [116] Willimott and Wagner, 2012 [117] He et al., 2013 [118]
miR-7	Downregulated in GBM	Luo et al., 2015 [119]
miR-185	Downregulated in GBM	Zhang et al., 2011 [120]
miR-24a	Upregulated in AML	Fabbri et al., 2008 [103]
miR-200	Downregulated in breast cancer	Mekala et al., 2018 [121]
miR-150	Downregulated in CTCL, AML	Jiang et al., 2012 [122] Ito et al., 2014 [123] Abe et al., 2017 [124]