Table 8.
Cell entry receptors for sendai virus.
| Sub-Type of Molecule | Receptor | Affinity to SeV | Ref. | Function in Normal Human Cells | Expression in Normal Human Cells |
|---|---|---|---|---|---|
| Glycoproteins | |||||
| Human asialoglyco-protein receptor 1 | ASGR1 | High | [145,156] | Removes the target glycoproteins from circulation in the liver | Hepatocytes [14,15,16] |
| Bovine glycoprotein 2 | Glycoprotein2/GP2 | High | [155] | - | |
| Human sialo-glycoprotein | Glycophorin A/GYPA/CD235a | High | [157] | Defines the antigenic determinants for some blood groups | Bone marrow, immune cells, [14,15,16] |
| Fucosylated glycans | |||||
| Tetra-saccharide | Sialyl Lewis-x antigen (sLeX/CD15s) | High | [158] | Serves as a blood group antigen and participates in cell-cell recognition process. | Bone marrow, erythrocytes [14,15,16] |
| Ceramide-dodeca-saccharide | VIM-2 antigen (CD65s) |
Unknown | Granulocytes and monocytes [158] | ||
| Sialylated gangliosides | |||||
| Ganglio-series | GD1a, GT1b, and GQ1b, | Not reported | [159] | Cell-cell recognition, adhesion, and signal transduction | Granulocytes, normal myeloid cells [160] |
| GT1a, GP1c | High | [161,162,163] | - | Many cell types, but mainly the cells of the nervous system [164] | |
| GD1a, GT1b | Moderate | [161,162,163] | - | ||
| GQ1b | Very high | ||||
| GM3 | Low | [165] | Cell–cell recognition | Blood cells, liver | |
| Neolacto-series | Sialosylparagloboside (SPG, NeuAcα2-3PG) | Very high | [163,166] | - | Common for non-neural cells |
| NeuAcα2-3I NeuAcα2-3i | [165] | - | |||
| NeuGca2-3I NeuAca2-6PG NeuAca2-6I |
Moderate | - | |||