Table 1.
Some of the YAP target genes significantly upregulated with NEK1 upregulation in head and neck squamous cell (HNSC) carcinoma (TCGA, firehose legacy) analyzed using cBIOPORTAL.
| Gene Name | Mean Log2 mRNA Expression ± SD in NEK1-Overexpressed Group | p-Value | q-Value |
|---|---|---|---|
| Zeb1 | 8.57 ± 1.00 | 3.68 × 10−7 | 5.153 × 10−6 |
| Zeb2 | 8.80 ± 1.05 | 7.237 × 10−6 | 6.617 × 10−5 |
| Ankrd36B | 4.33 ± 0.93 | 1.410 × 10−4 | 8.367 × 10−4 |
| Ankrd11 | 11.55 ± 0.49 | 1.159 × 10−3 | 4.984 × 10−3 |
| BirC2 | 10.46 ± 0.96 | 0.0187 | 0.0498 |
| BirC6 | 11.13 ± 0.49 | 3.91 × 10−12 | 2.80 × 10−10 |
| HoxB3 | 6.44 ± 2.11 | 0.0169 | 0.0458 |
| ARID1B | 10.84 ± 0.46 | 4.14 × 10−10 | 1.57 × 10−8 |
| WSB2 | 11.05 ± 0.45 | 2.016 × 10−4 | 1.136 × 10−3 |
| CAT | 10.01 ± 0.68 | 3.621 × 10−4 | 1.872 × 10−3 |
| ABCB1 | 5.11 ± 1.45 | 0.0111 | 0.0327 |
| PTX3 | 5.33 ± 2.12 | 1.994 × 10−4 | 1.126 × 10−3 |