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. 2020 Dec 7;10(12):1643. doi: 10.3390/biom10121643

Figure 1.

Figure 1

(A) The translocases of the mitochondrial outer and inner membranes, TOMs and TIMs, in Saccharomyces cerevisiae. TOM complex consists of Tom40, Tom70, Tom20, Tom22, Tom5, Tom6, and Tom7. The two TIM complexes are TIM23 and TIM22. The core components of the TIM23 complex are Tim23, Tim17, and Tim50. Tim21 helps to connect TIM23 with the TOM complex and often with the respiratory complex III. Mgr2 couples Tim21 to TIM23 core. TIM23 associates with the PAM complex that consists of Tim44, Hsp70, Pam16, Pam17, Pam18, and MgeI. The major component of the TIM22 complex is Tim22, and other components include Tim54, Tim12, Tim18, and Sdh3. The five small TIMS are Tim8, Tim9, Tim10, Tim12, and Tim13. The Tim9, Tim10 and the Tim8, Tim13 form two separate heterohexameic complexes in the intermembrane space that carry cargo proteins from the TOM complex to TIM22 complex. (B) The ATOM and the single TIM complex in Trypanosoma brucei. The major component of the ATOM complex, Atom40, and other subunits Atom14, Atom11, Atom12, Atom19, Atom46, and Atom69 are shown. Atom36 often associates with Atom40 but is not a part of this complex. The major component of the TbTIM complex is TbTim17. The TbTim62, TbTim42, Rhom I, and Rhom II are membrane integral proteins. TbTim50 is also membrane integrated but possesses a C-terminal domain exposed in the IMS. TbTim54 is a peripherally associated IMS protein. Location of ACAD is not known but expected to be in the matrix. Recent studies have shown that TbPam27 was membrane bound. Small TbTims are associated with the TbTim17 complex. The Cytosol, mitochondrial outer membrane (MOM), Intermembrane space (IMS), mitochondrial inner membrane (MIM), and matrix are labeled. The picture was drawn using the program (Biorender) available online.