Table 2.
Components of the TIM complexes in different organisms.
| Complex | Yeast/Fungi | Human | Plant | Trypanosomatids |
|---|---|---|---|---|
| TIM23 | Tim23 Tim17 Tim50 Tim21 Mgr2 |
TIMM23 TIMM17 TIMM50 |
Tim23 Tim17 Tim50 Tim21 |
|
| PAM | Pam18 Pam16 Pam17 Tim44 mHSP70 Mge-1 |
DnaJC19 a DnaJC15 a Magma b Mortalin/HSPA9 c |
Pam18 Pam16 Tim14 Tim44 Hsp70 Mge1 |
Pam27 mHSP70 Mge1 Pam16 Pam18 |
| TIM22 | Tim22 Tim54 Tim18 Sdh3 Tim12 |
TIMM22 TIMM29 AGK |
Tim22 | |
| Small Tims | Tim9 Tim10 Tim8 Tim13 Tim12 |
Tim9 Tim10a Tim10b Tim8 Tim13 |
Tim9 Tim10 Tim8 Tim13 |
Tim9 Tim10 Tim8/13 Tim11 Tim12 Tim13 |
| TbTIM d | Tim17 Tim62 Tim42 Tim50 Tim54 Rhomboid I Rhomboid II ACAD Small Tims |
a Human DnaJC19 and DnaJC15 are functional homologues of yeast Pam18. bMagma is the homologue of yeast Pam16. c Mortalin (HSPA9) is the mitochondrial Hsp70. d TBTIM complex in trypanosomatids possesses TbTim17 and several trypanosome-specific components.