. 2020 Dec 7;9(12):2626. doi: 10.3390/cells9122626

Table 1.

The expression of TREM1 and TREM2 in liver-related immune cells.

Name	Cell Type	Cell/Animal	Expression Change	Biological Function	Induction Time	Involved Cytokine	Induction Method	Involved Pathway	Ref
TREM1	Human monocyte	Cell	Up	Promote inflammation	24 h	IL-1β, TNF-α, IL-8	LPS	/	[56]
	Rat macrophage	Cell	Up	Promote inflammation	24/48 h	TNF-α, IL-8	LPS	NF-κB	[57]
	Liver macrophage	Animal, TLR4-mutant	Up	/	3 h	TNF-α, IL-1β	LPS	TLR4	[18]
	Liver endothelial cell	Animal, TLR4-mutant	Up	/	3 h	TNF-α, IL-1β	LPS	TLR4	[18]
	Hepatic stellate cell	Animal, TREM1^−/−	/	Promote fibrosis	6 w	ACTA2, MMP10, TIMP1	CCL₄	/	[58]
	Kupffer cell	Animal, TREM1^−/−	/	Promote inflammation	6 w	CCL9, CXCL2, TGF-β	CCL₄	/	[58]
	Neutrophil	Alcoholic liver disease model	/	Promote inflammation	5 w	MCP-1, TNF-α, IL-1β,	Lieber–DeCarli liquid diet	TLR	[59]
TREM2	Bone marrow macrophage	Animal, TREM2^−/−	/	Suppress inflammation	24 h	IL-6 IL-1β	LPS	TLR4	[60]
	Peritoneal macrophage	Animal, TREM2^−/−	/	Suppress inflammation	6 h	IL-6, TNF-α	LPS	TLR4	[51]
	Peritoneal macrophage	Cell	Down	/	1 h	IL-6, TNF-α	LPS	TLR4	[51]
	Liver macrophage	Animal, TLR4-mutant	Down	/	3 h	TNF-α, IL-1β	LPS	TLR4	[18]
	Liver endothelial cell	Animal, TLR4-mutant	Down	/	3 h	TNF-α, IL-1β	LPS	TLR4	[18]
	Kupffer cell	TREM2^−/−	/	Suppress infection	40 h	/	Malaria parasite	/	[16]
	Hepatic stellate cell	Cell	Up	Suppress inflammation	8 w	/	CCL₄	TLR4	[20]
	Hepatic stellate cell	Animal, TREM2^−/−	/	Suppress inflammation	8 w	/	CCL₄	TLR4	[20]