. 2020 Dec 7;12(12):1188. doi: 10.3390/pharmaceutics12121188

Table 3.

Molecules delivered by hydrogel drug delivery systems and detected by fluorescence intensity. N.G: Not given; N.A: Not applicable; Ex: Excitation; Em: emission; Ref: reference; BSA: bovine serum albumin; FITC: luorescein-5-isothiocyanate; SYBR: Synergy Brands, Inc.

Hydrogel Material(s)	Molecule	Molecule Function	Application	Wavelength of Detection (nm)	Ref
Gelatin	Fluorescein	Model hydrophobic molecule	Tissue engineering	Ex: 485, Em: 535	[15]
Poly(ethylene glycol) dimethacrylate, poly lactic-co-glycolic acid	Paclitaxel-Oregon Green^TM	Anticancer	Local cancer therapy	Ex: 488	[45]
Hyaluronan, alginate, gellan gum	Dextran-FITC	Diffusion model	Diffusion	Ex: 488, Em: 496–650	[89]
Hyaluronic acid, poly γ-glutamic acid	BSA-FITC	Model molecule	Cartilage tissue engineering	Ex: 493	[8]
Aptamer-tethered single-stranded DNA	Doxorubicin	Anticancer	Cancer	Em: 510	[90]
Aptamer-tethered single-stranded DNA	SYBR Green I-dye	Model molecule	Cell imaging	Em: 497	[90]
Carbon Dot, protoporphyrin IX, DNA	protoporphyrin IX	Antibacterial	Antibacterial photodynamic therapy	Em:410	[91]
DNA, Ag, agarose	Atto425 dye	Dye	Release model	Ex: 355, Em: 460	[92]
DNA, Ag, agarose	Atto550 dye	Dye	Release model	Ex: 355, Em: 460	[92]
Gelatin norbornene, poly(ethylene glycol) dithiol	microRNA	Cell differentiation (osteogenic)	Tissue engineering	N.G	[93]