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. 2020 Nov 20;12(23):24228–24241. doi: 10.18632/aging.104134

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Copyright: © 2020 Tan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Lasso analysis and Kaplan-Meier curve for the patients in the TCGA, ICGC and FUSCC cohorts. (A) Representative heatmap of the DEGs significantly related to OS time identified by the log-rank test in the TCGA cohort. (B) LASSO coefficient profiles of the 12 glycolysis and lipid metabolism-based genes. LASSO, least absolute shrinkage and selection operator method. (C) Risk score analysis of the differentially expressed DEG signatures of PDAC. Risk scores of DEG signatures (top); survival status and duration of cases (middle); low-score and high-score groups for the three genes (bottom). (D) The Kaplan-Meier plot (low risk vs. high risk PDAC cases) of 5-year overall survival in the TCGA cohort. (E) Time-dependent ROC analyses at 1, 3, and 5 years in the TCGA cohort. (F) The Kaplan-Meier plot (low risk vs. high risk PDAC cases) of 5-year overall survival in the ICGC cohort. (G) Time dependent ROC analyses at 1, 3, and 5 years in the ICGC cohort. (H) The Kaplan-Meier plot (low risk vs. high risk PDAC cases) of 5-year overall survival in the FUSCC cohort (I). Time dependent ROC analyses at 1, 3, and 5 years in the FUSCC cohort.