Table 3. Hazard ratios (HR) of FOXO3 minor allele carriers vs. major allele homozygotes with total mortality by diabetes, CHD, and hypertension.
| With a CMD | Without a CMD | |||||
| SNP | Cardiometabolic disease | Model* | HR (95% CI) ** | P | HR (95% CI) | P |
| rs2802292 | Diabetes | 1 | 0.84 (0.74-0.95) | 0.0064 | 0.94 (0.87-1.01) | 0.11 |
| (1010, 2525) *** | 2 | 0.78 (0.68-0.89) | 0.0003 | 0.93 (0.85-1.01) | 0.08 | |
| CHD | 1 | 0.84 (0.73-0.97) | 0.021 | 0.94 (0.88-1.02) | 0.13 | |
| (738, 2846) | 2 | 0.79 (0.67-0.93) | 0.0055 | 0.92 (0.85-1.00) | 0.04 | |
| Hypertension | 1 | 0.89 (0.81-0.97) | 0.0085 | 0.94 (0.85-1.04) | 0.24 | |
| (1919, 1665) | 2 | 0.83 (0.75-0.92) | 0.0003 | 0.94 (0.84-1.04) | 0.22 | |
| rs1935952 | Diabetes | 1 | 0.84 (0.74-0.96) | 0.0075 | 0.95 (0.88-1.03) | 0.25 |
| (1010, 2521) | 2 | 0.78 (0.68-0.90) | 0.0005 | 0.95 (0.87-1.03) | 0.22 | |
| CHD | 1 | 0.85 (0.73-0.98) | 0.030 | 0.95 (0.88-1.03) | 0.20 | |
| (738, 2842) | 2 | 0.81 (0.68-0.96) | 0.015 | 0.93 (0.85-1.01) | 0.08 | |
| Hypertension | 1 | 0.89 (0.82-0.98) | 0.017 | 0.95 (0.86-1.05) | 0.34 | |
| (1917, 1663) | 2 | 0.83 (0.75-0.92) | 0.0002 | 0.97 (0.87-1.08) | 0.60 | |
| rs2253310 | Diabetes | 1 | 0.84 (0.74-0.96) | 0.0076 | 0.94 (0.87-1.01) | 0.11 |
| (1010, 2523) | 2 | 0.78 (0.69-0.90) | 0.0004 | 0.93 (0.85-1.01) | 0.08 | |
| CHD | 1 | 0.84 (0.73-0.97) | 0.021 | 0.95 (0.88-1.02) | 0.14 | |
| (738, 2844) | 2 | 0.79 (0.67-0.93) | 0.0055 | 0.92 (0.85-1.00) | 0.04 | |
| Hypertension | 1 | 0.89 (0.81-0.97) | 0.0088 | 0.94 (0.86-1.04) | 0.25 | |
| (1918, 1664) | 2 | 0.83 (0.75-0.92) | 0.0003 | 0.94 (0.84-1.04) | 0.24 | |
| rs2764264 | Diabetes | 1 | 0.85 (0.75-0.96) | 0.0097 | 0.95 (0.88-1.03) | 0.20 |
| (1009, 2521) | 2 | 0.80 (0.70-0.92) | 0.0014 | 0.95 (0.87-1.04) | 0.25 | |
| CHD | 1 | 0.85 (0.73-0.99) | 0.034 | 0.95 (0.89-1.03) | 0.21 | |
| (736, 2843) | 2 | 0.81 (0.69-0.96) | 0.015 | 0.94 (0.86-1.02) | 0.13 | |
| Hypertension | 1 | 0.91 (0.83-1.00) | 0.041 | 0.94 (0.85-1.03) | 0.20 | |
| (1915, 1664) | 2 | 0.86 (0.78-0.95) | 0.0028 | 0.95 (0.85-1.06) | 0.38 | |
| rs2802288 | Diabetes | 1 | 0.84 (0.74-0.95) | 0.0062 | 0.93 (0.86-1.01) | 0.10 |
| (1009, 2516) | 2 | 0.78 (0.68-0.89) | 0.0002 | 0.92 (0.85-1.01) | 0.07 | |
| CHD | 1 | 0.84 (0.72-0.97) | 0.0182 | 0.94 (0.88-1.02) | 0.13 | |
| (736, 2838) | 2 | 0.79 (0.67-0.93) | 0.0047 | 0.92 (0.84-0.99) | 0.03 | |
| Hypertension | 1 | 0.89 (0.81-0.97) | 0.0084 | 0.94 (0.85-1.04) | 0.22 | |
| (1915, 1659) | 2 | 0.83 (0.75-0.92) | 0.0003 | 0.93 (0.84-1.04) | 0.19 | |
| rs3800230 | Diabetes | 1 | 0.89 (0.77-1.02) | 0.1038 | 0.96 (0.88-1.05) | 0.38 |
| (998, 2501) | 2 | 0.88 (0.76-1.02) | 0.095 | 0.93 (0.85-1.03) | 0.17 | |
| CHD | 1 | 0.96 (0.81-1.14) | 0.68 | 0.94 (0.86-1.02) | 0.12 | |
| (731, 2817) | 2 | 0.92 (0.76-1.11) | 0.3832 | 0.93 (0.85-1.01) | 0.10 | |
| Hypertension | 1 | 0.92 (0.83-1.02) | 0.099 | 0.94 (0.85-1.05) | 0.30 | |
| (1901, 1647) | 2 | 0.89 (0.79-0.99) | 0.033 | 0.95 (0.84-1.07) | 0.38 | |
| rs9398171 | Diabetes | 1 | 0.86 (0.76-0.97) | 0.015 | 0.95 (0.88-1.03) | 0.21 |
| (1002, 2508) | 2 | 0.81 (0.70-0.92) | 0.0017 | 0.95 (0.87-1.04) | 0.24 | |
| CHD | 1 | 0.85 (0.73-0.99) | 0.032 | 0.96 (0.89-1.03) | 0.26 | |
| (732, 2827) | 2 | 0.81 (0.68-0.96) | 0.013 | 0.94 (0.87-1.02) | 0.14 | |
| Hypertension | 1 | 0.91 (0.83-0.99) | 0.033 | 0.95 (0.86-1.05) | 0.30 | |
| (1905, 1654) | 2 | 0.85 (0.77-0.94) | 0.0019 | 0.96 (0.86-1.07) | 0.50 | |
| rs12212067 | Diabetes | 1 | 0.92 (0.78-1.08) | 0.31 | 0.95 (0.86-1.05) | 0.28 |
| (1005, 2502) | 2 | 0.88 (0.74-1.05) | 0.15 | 0.94 (0.84-1.05) | 0.27 | |
| CHD | 1 | 0.90 (0.74-1.10) | 0.30 | 0.94 (0.86-1.03) | 0.19 | |
| (732, 2824) | 2 | 0.90 (0.73-1.12) | 0.36 | 0.93 (0.84-1.03) | 0.17 | |
| Hypertension | 1 | 0.90 (0.80-1.00) | 0.056 | 0.96 (0.85-1.09) | 0.51 | |
| (1903, 1653) | 2 | 0.88 (0.78-0.99) | 0.037 | 0.96 (0.84-1.11) | 0.60 | |
| Haplotype**** | Diabetes | 1 | 0.83 (0.70-0.99) | 0.034 | 0.94 (0.85-1.05) | 0.26 |
| (661, 1793) | 2 | 0.77 (0.64-0.93) | 0.0071 | 0.93 (0.82-1.04) | 0.19 | |
| CHD | 1 | 0.85 (0.69-1.05) | 0.12 | 0.93 (0.84-1.03) | 0.15 | |
| (526, 1956) | 2 | 0.83 (0.66-1.04) | 0.10 | 0.90 (0.81-1.01) | 0.07 | |
| Hypertension | 1 | 0.87 (0.77-0.98) | 0.022 | 0.94 (0.81-1.09) | 0.43 | |
| (1331, 1151) | 2 | 0.82 (0.72-0.93) | 0.0003 | 0.93 (0.84-1.04) | 0.23 | |
* 1: Age-adjusted; 2: Covariate-adjusted, Covariates in Cox model: age, BMI, glucose, smoking (pack-year), alcohol intake (oz/mo), physical activity index, depression, cancer, and stroke.
** HR (95% CI) of FOXO3 minor allele carrier vs. major allele homozygotes on mortality estimated from the Cox regression model.
*** Number of subjects with a CMD, without a CMD.
**** Haplotype comprised minor allele frequencies of SNPs rs2253310 (C), rs2802288 (A), rs2802292 (G), rs2764264 (C), rs9398171 (C), rs12212067 (G), and rs3800230 (G).