Figure 1.

Binding rate of HKa* at 80 nM in MOPS pH 7.5. Dose response effect of tetra repeat in coincubation in presence or Zn²⁺ or Cu²⁺ (10 µM). Data are the mean ± SEM of three different experiments performed in triplicate. Statistically significant differences are indicated with * = p < 0.05 and **** = p < 0.0001 vs. HKa 80 nM (One-Way ANOVA + Dunnett’s test).