Figure 1.

Assessment of the cardiac functional parameters by echocardiography before administration of doxorubicin (basal values), at the end of doxorubicin administration (2 weeks values) and two weeks after termination of doxorubicin treatment (4 weeks values) in normotensive, transgene-negative Hannover Sprague-Dawley (HanSD) and hypertensive, Ren-2 transgenic (TGR) rats. Cardiac output (A), stroke volume (B), left ventricle ejection fraction (C), left ventricle fraction shortening (D), heart rate (E). * p < 0.05 compared with untreated animals of the same strain at the same time point. The values are means ± SEM.