Figure 6.

The second part of the data for the left ventricular cardiac function assessment by invasive hemodynamic analysis two weeks after the last doxorubicin injection (i.e., at the end of the experimental protocol) in normotensive, transgene-negative Hannover Sprague-Dawley (HanSD) and hypertensive, Ren-2 transgenic (TGR) rats. End-systolic pressure volume relationship (ESPVR) (A), end-diastolic pressure volume relationship (EDPVR) (B), left ventricle ejection fraction (C), preload recruitable stroke work (D), left ventricle wall stress (E), ventricular-arterial coupling (F). * p <0.05 compared with untreated animals of the same strain. The values are means ± SEM. ^# p < 0.05 compared with untreated HanSD rats.