Antioxidation
|
In vivo |
LPS-induced acute lung injury mice |
Naringenin; 100 mg/kg, p.o. |
Levels of H2O2 and MDA ↓ |
[36] |
In vivo |
Benzo[a]pyrene-induced rats |
Naringenin; 100 mg/kg, p.o. |
Levels of GSH, GPx, GST, GR, SOD, CAT, and XO ↑; Expression of COX-2 through blockage of NF-κB ↓ |
[66] |
In vitro |
Paraquat-induced BEAS-2B cell line |
Naringenin; 100 μM |
Generation of ROS ↓; Antioxidant-related genes including GPX2, GPX3, GPX5, and GPX7 and Nrf2 activity ↑ |
[67] |
In vivo |
Wood smoke-exposed rats |
Naringin; 80 mg/kg, p.o. |
The activities of SOD and CAT ↑; Levels of NO ↓ |
[70] |
In vivo |
Monocrotaline-induced pulmonary hypertension rats |
Naringenin; 50 mg/kg, p.o. |
GSH content and eNOS protein expression ↑; Expression of iNOS ↓ |
[71] |
In vitro |
LPS-induced RAW 264.7 cell line |
Naringenin NPs; 25 μg/mL |
Expression of iNOS and COX-2 and the production of NO ↓ |
[55] |