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. 2020 Dec 8;10(12):1644. doi: 10.3390/biom10121644

Table 2.

Summary of antioxidative activities of naringenin and naringin.

Pharmacological Activity Type of Study Study Subject Pharmacological Aspects Findings Ref.
Antioxidation In vivo LPS-induced acute lung injury mice Naringenin; 100 mg/kg, p.o. Levels of H2O2 and MDA ↓ [36]
In vivo Benzo[a]pyrene-induced rats Naringenin; 100 mg/kg, p.o. Levels of GSH, GPx, GST, GR, SOD, CAT, and XO ↑; Expression of COX-2 through blockage of NF-κB ↓ [66]
In vitro Paraquat-induced BEAS-2B cell line Naringenin; 100 μM Generation of ROS ↓; Antioxidant-related genes including GPX2, GPX3, GPX5, and GPX7 and Nrf2 activity ↑ [67]
In vivo Wood smoke-exposed rats Naringin; 80 mg/kg, p.o. The activities of SOD and CAT ↑; Levels of NO ↓ [70]
In vivo Monocrotaline-induced pulmonary hypertension rats Naringenin; 50 mg/kg, p.o. GSH content and eNOS protein expression ↑; Expression of iNOS ↓ [71]
In vitro LPS-induced RAW 264.7 cell line Naringenin NPs; 25 μg/mL Expression of iNOS and COX-2 and the production of NO ↓ [55]