Figure 2.

Effects of delayed treatment with multiple-dose administration of BXM or PR in chickens infected with HPAIV, A/BS/Akita/1/16. Eight chickens per group were infected with 10 CLD₅₀/100 µL (10^5.3 EID₅₀) of the HPAIV and treated with 20 mg/kg of either BXM or PR for 24 h to 5 days post-infection; the untreated group was kept as the control. (a) Survival and clinical signs of half the infected birds was followed until 14 dpi; vertical black arrows indicate the treatment schedule. (b) Virus recovery from organs collected at 3 dpi from four chickens of each group was assessed in monolayer MDCK cells. The viral titer calculated as the average (n = 4) of each organ in the treatment group was compared to that of the control group; bar indicates the standard deviation. (*, p < 0.05).