Fig. 1.

Hazard ratios of the serum copper-to-zinc-ratio and serum copper and serum zinc with risk of an incident infection among 1975 men, evaluated by restricted cubic splines from Cox proportional hazards models. The model is adjusted for age (years), examination year, history of coronary heart disease, stroke, cancer or diabetes (yes/no); smoking (never smoker, previous smoker, current smoker < 20 cigarettes/day, current smoker > 20 cigarettes/day); education (years); income (euros/year); intake of alcohol (g/week); leisure-time physical activity (kcal/day); and body mass index. The solid line represents the central risk estimate and the shaded area the 95% confidence interval. The dotted vertical lines correspond to 10th, 25th, 50th, 75th and 90th percentile of the serum copper-to-zinc-ratio or serum copper or zinc concentrations