TABLE 3.
Q1(low) | Q2 | Q3 | Q4 | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Model | Cases | HR | Cases | HR (95% CI)2,3 | Cases | HR (95% CI)b,c | Cases | HR (95% CI)b,c | P-trend | P-heterogeneity4 |
Dietary isoflavone intake | ||||||||||
Median age, y | ||||||||||
≤53 | 197 | 1.00 | 176 | 0.91 (0.74, 1.12) | 203 | 1.13 (0.92, 1.38) | 156 | 0.98 (0.79, 1.23) | 0.78 | 0.68 |
>53 | 428 | 1.00 | 433 | 0.92 (0.80, 1.06) | 494 | 1.00 (0.87, 1.15) | 502 | 0.93 (0.80, 1.08) | 0.75 | |
Smoking status | ||||||||||
Ever | 240 | 1.00 | 209 | 0.80 (0.66, 0.96) | 249 | 0.92 (0.77, 1.11) | 237 | 0.83 (0.68, 1.00) | 0.69 | 0.15 |
Never | 385 | 1.00 | 400 | 1.01 (0.87, 1.16) | 448 | 1.13 (0.98, 1.30) | 421 | 1.03 (0.88, 1.21) | 0.77 | |
Menopausal status | ||||||||||
Premenopausal | 152 | 1.00 | 152 | 1.02 (0.81, 1.28) | 166 | 1.05 (0.83, 1.32) | 146 | 0.81 (0.63, 1.04) | 0.03 | 0.68 |
Postmenopausal | 147 | 1.00 | 159 | 1.02 (0.81, 1.28) | 191 | 1.21 (0.96, 1.51) | 153 | 0.93 (0.72, 1.19) | 0.81 | |
Cancer site | ||||||||||
Colon | 370 | 1.00 | 384 | 0.97 (0.84, 1.13) | 422 | 1.05 (0.91, 1.23) | 421 | 1.01 (0.85, 1.19) | 0.81 | 0.80 |
Rectal | 217 | 1.00 | 206 | 0.93 (0.76, 1.13) | 243 | 1.09 (0.89, 1.33) | 208 | 0.92 (0.73, 1.15) | 0.62 | |
Dietary soy protein intake | ||||||||||
Median age, y | ||||||||||
≤53 | 201 | 1.00 | 185 | 0.97 (0.79, 1.18) | 182 | 1.01 (0.82, 1.24) | 164 | 1.04 (0.84, 1.30) | 0.99 | 0.77 |
>53 | 425 | 1.00 | 440 | 0.94 (0.82, 1.07) | 491 | 0.98 (0.85, 1.12) | 501 | 0.92 (0.79, 1.07) | 0.63 | |
Smoking status | ||||||||||
Ever | 238 | 1.00 | 214 | 0.82 (0.68, 0.99) | 250 | 0.94 (0.78, 1.12) | 233 | 0.81 (0.67, 0.99) | 0.62 | 0.09 |
Never | 388 | 1.00 | 411 | 1.04 (0.90, 1.20) | 423 | 1.03 (0.89, 1.19) | 432 | 1.05 (0.90, 1.23) | 0.75 | |
Menopausal status | ||||||||||
Premenopausal | 152 | 1.00 | 165 | 1.09 (0.87, 1.36) | 143 | 0.88 (0.69, 1.12) | 156 | 0.87 (0.68, 1.12) | 0.07 | 0.40 |
Postmenopausal | 148 | 1.00 | 166 | 1.07 (0.86, 1.34) | 175 | 1.10 (0.88, 1.38) | 161 | 0.98 (0.77, 1.26) | 0.67 | |
Cancer site | ||||||||||
Colon | 385 | 1.00 | 385 | 0.94 (0.81, 1.09) | 406 | 0.95 (0.82, 1.10) | 421 | 0.95 (0.80, 1.12) | 0.66 | 0.67 |
Rectal | 204 | 1.00 | 221 | 1.07 (0.88, 1.30) | 233 | 1.12 (0.92, 1.38) | 216 | 1.04 (0.83, 1.31) | 0.80 |
Based on the cohort- and sex-specific quartiles. Please see Supplemental Table 2 for specific cutpoint values for each cohort. CRC, colorectal cancer; Q, quartile.
Adjusted for age, sex, total energy, cohort, smoking status, alcohol consumption, physical activity, BMI, family history of colorectal cancer, intake of red meat, vegetable intake, folate intake, and menopausal status in women.
Complete case analysis based on total sample size of 186,755 with 2589 colorectal cancer cases.
Calculated using the likelihood ratio test for nested models for the multiplicative interaction term. P for overall heterogeneity was calculated to determine differences by cancer site.