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. 2020 Dec 22;1(9):100157. doi: 10.1016/j.xcrm.2020.100157

Figure 5.

Figure 5

P. falciparum In Vitro Stimulation Activates All Subsets of Tfh

PBMCs from malaria-naive healthy donors (n = 10) were stimulated with P. falciparum-infected RBCs or uninfected RBCs (iRBCs, uRBCs) for 5 days. Each individual was tested once.

(A and B) ICOS, (C and D) CD38, and (E and F) Ki67 expression on each Tfh subset was compared between uRBC- and iRBC-stimulated cells. (A), (C), and (E) are representative data. (B), (D), and (F) Boxplots are Tukey style, with median and IQR. Whiskers are to data point no further than 1.5 × IQR; dots are outlying points. Paired data are joined by lines. Wilcoxon signed-rank test indicated comparing uRBC to iRBC stimulation in each individual.