Figure 7.

Th2-Tfh Cells Are Associated with Antibody Induction, and Th1-Tfh Cells Are Associated with Plasma Cell Expansion

(A) To assess total breadth and magnitude of antibody response, responses were categorized as negative (0) or low (1) and high (2) responses and combined to calculate a total antibody score.

(B) Association between antibody score and the frequency change of ICOS⁺ cTfh cells compared to day 0 at each time point.

(C) Association between antibody score and the frequency change of each subset of ICOS⁺ cTfh cells at day 8.

(D) Association between plasma cell induction and ICOS⁺ cTfh cells at day 14/15 following infection.

(B–D) Red line is loess. Spearman correlation and ρ are indicated. For (B) and (C), p-adj indicates adjusted p values using the Bonferroni-Holm method for the 6 Tfh comparisons with antibody.

See also Figures S4 and S5.